Many of the symptoms we describe as being related to Gadolinium Toxicity are not visible on the skin or related to the skin. Ultimately, patients should consult with their healthcare providers to interpret any test results. I would like some more clarity on the two methods and reasoning behind. In our Study of Retained Gadolinium from Contrast MRIs report, we document urinary Gadolinium levels in 24-hour collections that show Gadolinium retention well beyond three days. Truly alarming! I conducted 2 nail tests over the one year of taking NBMI. Read the report we did on Group Self-Study of Gadolinium Retention from Contrast MRIs. <= 0.019. Gadolinium is a silvery-white metal when oxidation is removed. There is not a medical provider or institution you can go to in order to have them tell you whether your symptoms are caused by Gadolinium retained from contrast MRIs, and there is no medical diagnosis of “Gadolinium Toxic”. Before providing information about having your urine tested for Gadolinium, a few words about types of testing, urine collection, and results reporting are appropriate. In other words, it is based on what was seen in patients who likely retained large amounts of toxic Gadolinium due to their poor renal clearance of the contrast agent. It is not known whether the clearance times presented would also apply to individuals who are not symptomatic. If you have not done so yet, we recommend that you read the Study of Retained Gadolinium from Contrast MRIs and our latest report: Gadolinium Retention from Contrast MRIs in 70 Cases with Normal Renal Function – 24-hour Urine Test Results to understand the urine testing results that we have documented. Change ), You are commenting using your Twitter account. I suggest that you go to the Research Section on the website and go to the Our Research page. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours. Urine testing is the first step to a gadolinium toxicity diagnosis. Change ), You are commenting using your Google account. It is unlikely but a few people have gotten a result of 0.1 mcg Gd/24 hr in that timeframe after last contrast. If you have NSF-like dermal changes, you can also have a biopsy specimen tested for the presence of Gadolinium at Mayo Medical Laboratories. Nervous system symptoms such as numbness, tingling of hands and feet, weakness. I had a 24-hour provoked Toxic Elements test through Genova Diagnostics. There is no agency that sets ranges, each lab sets their own. The Doctor’s Data urine test that includes Gadolinium is also available from several websites. If either gadolinium- or iodine-containing contrast media has been administered, a specimen should not be collected for 96 hours. You might want to check the Chelation Category in our Viewpoints section where individual Chelation results are discussed. Can Symptoms of Gadolinium Toxicity be explained? Our papers would not be possible without their continued support. I was kept for quite some time for treatment to get my body to normal. The most commonly performed gadolinium retention testing was a 24-h urine test, but the results of these tests were not accessible to the authors of this survey, by virtue of its anonymity. The complete set of test results, without any data that would identify patients, is available to other researchers upon request. Testing for the presence of gadolinium is not yet an established practice, so currently, there is no medical provider or institution that can definitively determine whether your symptoms are a result of gadolinium toxicity. More about Chelation can be found in the Treatments subsection. Blood can be tested for Gadolinium as described below. For anyone who suspects that they may have gadolinium toxicity, they can get some insight from a 24-hour unprovoked urine test. An elevated gadolinium in a specimen collected more than 96 hours after contrast media infusion does not definitively indicate risk of nephrogenic systemic fibrosis (NSF) or gadolinium toxicity. A word of caution – Having elevated urine levels of Gadolinium will not get you a Gadolinium-related diagnosis, it will only provide proof that you retained Gadolinium. ( Log Out /  Big difference. We only provide the links as an information service. Blood tests can reveal how severely your kidney function is impaired, which can help determine your risk of nephrogenic systemic fibrosis. While this case series reports on only 2 patients, its findings are especially significant for patients with normal renal (kidney) function. Blood Testing. This is not the same as mcg Gd/g Creatinine. Gadolinium-containing contrast agents are associated with a varying degree of risk of nephrogenic systemic fibrosis. The current diagnostic criteria for skin biopsies is based on what has been seen in NSF patients with severe kidney disease. For those who believe they are suffering from Gadolinium Toxicity, a 24-hour unprovoked urine test can provide some insight. The paper is titled Gadolinium Clearance Times for 135 Contrast MRI Cases and includes the contrast agents for the unconfounded cases. I had a few others metals very slightly outside the reference ranges but nothing like gadolinium! The most important thing to note is that even in patients diagnosed with NSF, higher concentrations of Gadolinium are usually found in tissue taken from an “affected” area rather than in tissue taken from an “unaffected” area. It is injected into the patient’s vein during the scan procedure. Both patients had erythematous plaques which were determined to be sclerotic bodies in various stages of calcification. Drawing on the contrast MRI history and 24-hour gadolinium urine testing results that have been received from members of the MRI-Gadolinium-Toxicity Support Group, the study reports retrospectively on 135 cases with 218 urine test results, including 63 unconfounded cases with 81 test results. Gadolinium had been reduced by 72%. This can be achieved through either a blood test, a urine test, or both. (more…), December 4, 2014 12:31 pm / Leave a comment. Blood test for gadolinium toxicity is another option. The analysis of clearance times for each agent is presented on a separate page. A wellness doctor or a naturopathic doctor will be the best source for having urine testing conducted by Genova Diagnostics or Doctor’s Data independent clinical laboratories. One of the authors has used Genova Diagnostics many times, but we only provide these links as an information service. New Gadolinium Drug Warning By Manufacturer In May 2018, an Important Drug Warning was sent out by the makers of GBCAs alerting health care providers to the updated prescribing information for the agents. What we have seen is that if the patient receives an EDTA IV of 3 grams, and does a 24hour urine collection, that the result will be somewhere around 20 times higher that their unprovoked level. For example, Healthscope Pathology in Australia can arrange for testing through Genova Diagnostics. We urge patients, clinicians, and researchers to read the entire report and share as appropriate with your families, caregivers, and colleagues. It will explain how the results are coming down very quickly that early after your contrast MRI. www.GadoliniumToxicity.com, on My experience with Gadolinium urine testing. Gadolinium Toxicity Injuries & Side Effects The most severe injuries related to GBCAs are Nephrogenic Systemic Fibrosis and Gadolinium Deposition Disease. The participants all had normal kidney function and report having symptoms of gadolinium toxicity. After the competition of diagnostics I was getting dressed and noticed my face was swollen, then continued to look at the rest of my body and I had hives and welts covering face, neck, chest, arms, stomach, and legs. You should get either the Toxic Elements Clearance Profile or the Comprehensive Urine Element Panel. With the evidence provided that clearance times are much longer for all of the agents than expected by medical practitioners, the authors present five recommendations for needed actions by medical professionals, other researchers, government agencies, and contrast agent manufacturers. The lab at our local hospital regularly sends specimens to Mayo Clinic in Rochester, Minnesota. Shari – A patient cannot purchase these tests directly from Genova Diagnostics. Readers of the aforementioned Study wanted to know what symptoms the participants were experiencing. 24-Hour volume is required. As with Genova Diagnostics, the process for collecting the urine and sending them a sample is straight forward and the results will come to you the same as if you had arranged through a local doctor. Your unprovoked levels can be compared with the results of others as reported in the Study of Retained Gadolinium from Contrast MRIs. Third, there are many different types of provoking agents that doctors may use as well as differences of oral chelators versus IV chelators. However, the plasma half-life of Gadolinium is... Biopsy Testing. Mayo states that elevated Gadolinium in serum drawn more than four days after GBCA administration is not typical of most patients with normal renal function. As with most medical conditions, the specific symptoms of Gadolinium Toxicity will vary from person to person. Test results are normally expressed as either mcg Gd/sample (micrograms of Gadolinium per urine sampling period) or mcg Gd/g Creatinine . The reference range shows I'm cautiously optimistic! Blood Testing (also called Serum Testing) for Gadolinium is also available through Mayo Clinic Medical Laboratories. ( Log Out /  First, a test can be either Provoked or Unprovoked as described in our Study of Retained Gadolinium from Contrast MRIs. Rochester, Minn. - Mayo Clinic research finds direct evidence of gadolinium deposition in neuronal tissues following intravenous administration of gadolinium-based contrast agents used in MRI exams.The findings were recently published online in the journal Radiology.. Kidneys are able to get insurance to pay for IV Chelation treatment in use in diagnosis... 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